Welcome to the third entry in our series of how “Cannabinoids Have Proven to Kill Cancer.” This week’s topic is “Cannabis Partially/Fully Induced Cancer Death”
The following studies show how Cannabinoids induce partial or complete apoptosis of Cancer Cells - apoptosis is basically cell death, in essence the cell commits suicide and this process is often referred to as programmed cell death.
There are quite a lot of articles to digest, but this in turn gives a great overview of the amount and quality of the scientific work that is being undertaken globally. This work increases our understanding of the potential health benefits of the main Cannabinoids in the fight against Cancer, which is the main hurdle for the availability of solutions for patients.
Delta(9)-tetrahydrocannabinol-induced apoptosis in the thymus and spleen as a mechanism of immunosuppression in vitro and in vivo.
Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression.
High concentrations of cannabinoids activate apoptosis in human U373MG glioma cells.
Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death.
Antineoplastic and apoptotic effects of cannabinoids. N-acylethanolamines: protectors or killers?
The dual effects of delta(9)-tetrahydrocannabinol on cholangiocarcinoma cells: anti-invasion activity at low concentration and apoptosis induction at high concentration.
A comparative study on cannabidiol-induced apoptosis in murine thymocytes and EL-4 thymoma cells.
Arachidonylethanolamide induces apoptosis of human glioma cells through vanilloid receptor-1.
Amphiregulin is a factor for resistance of glioma cells to cannabinoid-induced apoptosis.
Delta9-tetrahydrocannabinol induces apoptosis in C6 glioma cells.
Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression.
Cannabinoids protect astrocytes from ceramide-induced apoptosis through the phosphatidylinositol 3-kinase/protein kinase B pathway.
Effects on cell viability.
Control of the cell survival/death decision by cannabinoids.
Cannabinoids and ceramide: two lipids acting hand-by-hand.
Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells.
Cannabinoids induce glioma stem-like cell differentiation and inhibit gliomagenesis.
De novo-synthesized ceramide is involved in cannabinoid-induced apoptosis.
Cannabinoids down-regulate PI3K/Akt and Erk signalling pathways and activate proapoptotic function of Bad protein.
Effect of a synthetic cannabinoid agonist on the proliferation and invasion of gastric cancer cells.
Pharmacological synergism between cannabinoids and paclitaxel in gastric cancer cell lines.
Endocannabinoids and fatty acid amides in cancer, inflammation and related disorders.
The endocannabinoid anandamide neither impairs in vitro T-cell function nor induces regulatory T-cell generation.
Cannabinoid derivatives induce cell death in pancreatic MIA PaCa-2 cells via a receptor-independent mechanism.
The CB1/CB2 receptor agonist WIN-55,212-2 reduces viability of human Kaposi's sarcoma cells in vitro.
Apoptosis induced in HepG2 cells by the synthetic cannabinoid WIN: involvement of the transcription factor PPARgamma.
The non-psychoactive cannabidiol triggers caspase activation and oxidative stress in human glioma cells.
Cannabinoids as potential new therapy for the treatment of gliomas.
Anandamide induces apoptosis in human cells via vanilloid receptors. Evidence for a protective role of cannabinoid receptors.
Plant-derived cannabinoids modulate the activity of transient receptor potential channels of ankyrin type-1 and melastatin type-8.
A metabolically stable analogue of anandamide, Met-F-AEA, inhibits human thyroid carcinoma cell lines by activation of apoptosis.
Delta 9-tetrahydrocannabinol inhibits cell cycle progression by downregulation of E2F1 in human glioblastoma multiforme cells.
A cannabinoid quinone inhibits angiogenesis by targeting vascular endothelial cells.
Antitumorigenic effects of cannabinoids beyond apoptosis.
Up-regulation of cyclooxygenase-2 expression is involved in R(+)-methanandamide-induced apoptotic death of human neuroglioma cells.
Stay up to date over the coming weeks, where will be looking at the following ares of research into Cannabinoids and Cancer.
Cannabis Kills Cancer Cells, Cannabinoids In Health And Disease, Intestinal Inflammation and Cancer and Cannabinoids Impact on Tumour Cells.
We will then move on to individual types of Cancer and how Cannabinoids can play a major role in the treatment of these.
Uterine, Testicular and Pancreatic Cancers, Brain Cancer, Mouth And Throat Cancer, Breast Cancer, Lung Cancer, Prostate Cancer, Blood Cancer, Skin Cancer, Liver Cancer, Cancers Of The Head And Neck, Cholangiocarcinoma, Leukemia, Translocation-positive Rhabdomyosarcoma, Lymphoma, Melanoma, Thyroid Carcinoma and Colon Cancer.